Glimepiride belongs to the sulfonylurea class of medications, which stimulate the pancreas to release more insulin.
Metformin works primarily by decreasing glucose production in the liver (hepatic gluconeogenesis), reducing gastrointestinal absorption, and increasing insulin sensitivity in target cells.
The combination provides a synergistic effect in lowering blood glucose levels.
This dual action helps achieve better overall glycaemic control than either drug alone.